The Dermatological Effects of Vitamin D: Addressing Pore Size and Skin Roughness
DOI:
https://doi.org/10.57214/jka.v9i1.837Keywords:
Dermatology, Skin pores, Skin roughness, Vitamin DAbstract
Vitamin D, or calciferol, is a fat-soluble vitamin produced endogenously when ultraviolet (UV) light triggers its synthesis in the skin. It also comes from food and supplements, existing as D2 (ergocalciferol) and D3 (cholecalciferol). Both forms convert into the active form, calcitriol, in the liver and kidneys, with D3 more effectively raising blood levels. Vitamin D supports bone health, regulates cellular functions, and offers anti-inflammatory, antioxidant, and neuroprotective benefits. It improves skin health by regulating oil production, soothing inflammation, promoting skin renewal, and strengthening the skin barrier. Deficiency (<20 ng/dL) weakens the skin barrier, causing dryness and roughness. The global prevalence of vitamin D deficiency is rising, with Southeast Asia, including Indonesia, experiencing rates between 35.1% and 91.7%. This study explores the relationship between vitamin D levels and skin health, focusing on pores and roughness in geriatric populations. This cross-sectional study analyzed 26 elderly, measuring vitamin D levels (Vitamin D 25-hydroxy (25(OH)D), skin pore size, and roughness (RGB analysis), with Spearman and partial correlation assessing relationships while controlling for age. Bivariate analysis showed a significant positive relationship between vitamin D levels and pore size (p = 0.03) and a strong, statistically significant relationship between pore size and skin roughness (p < 0.01). Vitamin D influences skin health, including pore size and texture. Monitoring vitamin D levels enables early intervention, improving skin appearance, reducing roughness, and preventing complications from vitamin D deficiency.
References
Amaro-Ortiz, A., Yan, B., & D’Orazio, J. A. (2014). Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation. Molecules, 19(5), 6202. https://doi.org/10.3390/MOLECULES19056202
Ao, T., Kikuta, J., & Ishii, M. (2021). The Effects of Vitamin D on Immune System and Inflammatory Diseases. Biomolecules, 11(11), 1624. https://doi.org/10.3390/BIOM11111624
Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020). Diet and Skin Aging—From the Perspective of Food Nutrition. Nutrients 2020, Vol. 12, Page 870, 12(3), 870. https://doi.org/10.3390/NU12030870
Chen, Q., Liu, L., & Zhang, Y. (2024). Vitamin D and wound healing: Assessing skin barrier function and implications for chloasma treatment. International Wound Journal, 21(1), e14541. https://doi.org/10.1111/IWJ.14541
Csekes, E., & Račková, L. (2021). Skin Aging, Cellular Senescence and Natural Polyphenols. International Journal of Molecular Sciences 2021, Vol. 22, Page 12641, 22(23), 12641. https://doi.org/10.3390/IJMS222312641
Danimayostu, A. A., Martien, R., Lukitaningsih, E., & Danarti, R. (2023). Vitamin D3 and Molecular Pathway of Skin Aging. Indonesian Journal of Pharmacy, 34(3), 357–371. https://doi.org/10.22146/IJP.4929
Dominguez, L. J., Farruggia, M., Veronese, N., & Barbagallo, M. (2021). Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment. Metabolites, 11(4). https://doi.org/10.3390/metabo11040255
Gutiérrez-Juárez, R., Pocai, A., Mulas, C., Ono, H., Bhanot, S., Monia, B. P., & Rossetti, L. (2006). Critical role of stearoyl-CoA desaturase–1 (SCD1) in the onset of diet-induced hepatic insulin resistance. Journal of Clinical Investigation, 116(6), 1686. https://doi.org/10.1172/JCI26991
He, X., Wan, F., Su, W., & Xie, W. (2023). Research Progress on Skin Aging and Active Ingredients. Molecules 2023, Vol. 28, Page 5556, 28(14), 5556. https://doi.org/10.3390/MOLECULES28145556
Janjetovic, Z., & Slominski, A. T. (2024). Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection. Cosmetics 2024, Vol. 11, Page 37, 11(2), 37. https://doi.org/10.3390/COSMETICS11020037
Janoušek, J., Pilařová, V., Macáková, K., Nomura, A., Veiga-Matos, J., Silva, D. D. da, Remião, F., Saso, L., Malá-Ládová, K., Malý, J., Nováková, L., & Mladěnka, P. (2022). Vitamin D: sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites. Critical Reviews in Clinical Laboratory Sciences, 59(8), 517–554. https://doi.org/10.1080/10408363.2022.2070595
Khammissa, R. A. G., Fourie, J., Motswaledi, M. H., Ballyram, R., Lemmer, J., & Feller, L. (2018). The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health. BioMed Research International, 2018. https://doi.org/10.1155/2018/9276380
Khazai, N., Judd, S. E., & Tangpricha, V. (2008). Calcium and Vitamin D: Skeletal and Extraskeletal Health. Current Rheumatology Reports, 10(2), 110. https://doi.org/10.1007/S11926-008-0020-Y
Mavar, M., Sorić, T., Bagarić, E., Sarić, A., & Matek Sarić, M. (2024). The Power of Vitamin D: Is the Future in Precision Nutrition through Personalized Supplementation Plans? Nutrients, 16(8), 1176. https://doi.org/10.3390/nu16081176
Miyamoto, K., Dissanayake, B., Omotezako, T., Takemura, M., Tsuji, G., & Furue, M. (2021). Daily fluctuation of facial pore area, roughness and redness among young japanese women; beneficial effects of galactomyces ferment filtrate containing antioxidative skin care formula. Journal of Clinical Medicine, 10(11), 2502. https://doi.org/10.3390/JCM10112502/S1
Miyamoto, K., Inoue, Y., Yan, X., Yagi, S., Suda, S., & Furue, M. (2023). Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months—An 11-Year Longitudinal Skin Aging Rejuvenation Study. Journal of Clinical Medicine, 12(3), 1168. https://doi.org/10.3390/JCM12031168/S1
Mostafa, W. Z., & Hegazy, R. A. (2014). Vitamin D and the skin: Focus on a complex relationship: A review. Journal of Advanced Research, 6(6), 793. https://doi.org/10.1016/J.JARE.2014.01.011
Rittié, L., & Fisher, G. J. (2015). Natural and Sun-Induced Aging of Human Skin. Cold Spring Harbor Perspectives in Medicine, 5(1), a015370. https://doi.org/10.1101/CSHPERSPECT.A015370
Russell, M. (2012). Assessing the Relationship between Vitamin D3 and Stratum Corneum Hydration for the Treatment of Xerotic Skin. Nutrients, 4(9), 1213. https://doi.org/10.3390/NU4091213
Siddiqee, M. H., Bhattacharjee, B., Siddiqi, U. R., & MeshbahurRahman, M. (2021). High prevalence of vitamin D deficiency among the South Asian adults: a systematic review and meta-analysis. BMC Public Health, 21(1), 1823. https://doi.org/10.1186/S12889-021-11888-1
Thadanipon, K., & Kitsongsermthon, J. (2020). Comparative study into facial sebum level, pore size, and skin hydration between oily-skinned and dry-skinned Thai women. Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 26(2), 163–168. https://doi.org/10.1111/SRT.12792
Yeon, H., & Nafaisa, A. (2024). Administration of vitamin D3 topical in increasing serum vitamin D level: A literature review. Journal of General - Procedural Dermatology & Venereology Indonesia, 8(1). https://doi.org/10.7454/jdvi.v8i1.1184
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