Peningkatan Kesehatan Mental dengan Pemantauan Kadar Vitamin D pada Kelompok Lanjut Usia
DOI:
https://doi.org/10.57214/jka.v9i1.890Keywords:
Depression, Geriatric-Depression-Scale, Vitamin-DAbstract
Vitamin D is a micronutrient required by the body. Vitamin D has various functions, including its potential to prevent depression. There are studies suggesting that people with depression are at risk of vitamin D deficiency. This study discusses the correlation between vitamin D and depression. This is a cross-sectional study designed to investigate the relationship between vitamin D levels and depression in elderly (≥ 60 years) residing at Bina Bhakti Nursing Home. Participants who meet the criteria underwent measurement of vitamin D levels and assessment for depression using the Geriatric Depression Scale (GDS). Spearman correlation is used as the statistical analysis to evaluate the relationship between variables. 93 respondents met the criteria with average age of 74.19 years (61-97 years). 77 respondents were female (82.8%) and 16 respondents (17.2%) were male. The mean vitamin D level was 9.78 ng/ml (1.07-25.6ng/mL) and the mean GDS score was 4.51 (0-15). The results of the analysis showed a significant negative correlation between vitamin D levels and GDS scale (-0.287, p-value=0.005). Low vitamin D levels are associated with increased GDS scores, indicating that it is important for the elderly to fulfill their vitamin D needs as an preventive measure against depression
References
Ajith, T. A., John, S., & Achu, S. (2022). Vitamin D status and its correlation with disease severity among patients presented with major depressive disorders in a tertiary health care hospital in South India. Pharmacology and Clinical Pharmacy Research, 7(1), 1. https://doi.org/10.15416/pcpr.v7i1.35041
Akpınar, Ş., & Karadağ, M. G. (2022). Is vitamin D important in anxiety or depression? What is the truth? Current Nutrition Reports, 11(4), 675–681. https://doi.org/10.1007/s13668-022-00441-0
Alavi, N. M., Khademalhoseini, S., Vakili, Z., & Assarian, F. (2019). Effect of vitamin D supplementation on depression in elderly patients: A randomized clinical trial. Clinical Nutrition, 38(5), 2065–2070. https://doi.org/10.1016/j.clnu.2018.09.011
Anglin, R. E. S., Samaan, Z., Walter, S. D., & Sarah, D. M. (2013). Vitamin D deficiency and depression in adults: Systematic review and meta-analysis. British Journal of Psychiatry, 202(2), 100–107. https://doi.org/10.1192/bjp.bp.111.106666
Berridge, M. J. (2017). Vitamin D and depression: Cellular and regulatory mechanisms. Pharmacological Reviews, 69(2), 80–92. https://doi.org/10.1124/pr.116.013227
Casseb, G. A. S., Kaster, M. P., & Rodrigues, A. L. S. (2019). Potential role of vitamin D for the management of depression and anxiety. CNS Drugs, 33(7), 619–637. https://doi.org/10.1007/s40263-019-00640-4
Cheng, Y. C., Huang, Y. C., & Huang, W. L. (2020). The effect of vitamin D supplement on negative emotions: A systematic review and meta-analysis. Depression and Anxiety, 37(6), 549–564. https://doi.org/10.1002/da.23025
Cuomo, A., Giordano, N., Goracci, A., & Fagiolini, A. (2017). Depression and vitamin D deficiency: Causality, assessment, and clinical practice implications. Neuropsychiatry, 7(5), 606–614. https://doi.org/10.4172/neuropsychiatry.1000255
De Koning, E. J., Lips, P., Penninx, B. W. J. H., Elders, P. J. M., Heijboer, A. C., Den Heijer, M., Bet, P. M., Van Marwijk, H. W. J., & Van Schoor, N. M. (2019). Vitamin D supplementation for the prevention of depression and poor physical function in older persons: The D-Vitaal study, a randomized clinical trial. American Journal of Clinical Nutrition, 110(5), 1119–1130. https://doi.org/10.1093/ajcn/nqz141
Di Gessa, G., Biddulph, J. P., Zaninotto, P., & de Oliveira, C. (2021). Changes in vitamin D levels and depressive symptoms in later life in England. Scientific Reports, 11(1), 1–8. https://doi.org/10.1038/s41598-021-87432-3
Giustina, A., Bouillon, R., Dawson-Hughes, B., Ebeling, P. R., Lazaretti-Castro, M., Lips, P., Marcocci, C., & Bilezikian, J. P. (2022). Vitamin D in the older population: A consensus statement. Endocrine, 79(1), 31–44. https://doi.org/10.1007/s12020-022-03208-3
Guzek, D., Kołota, A., Lachowicz, K., Skolmowska, D., Stachoń, M., & Głąbska, D. (2023). Effect of vitamin D supplementation on depression in adults: A systematic review of randomized controlled trials (RCTs). Nutrients, 15(4). https://doi.org/10.3390/nu15040951
Hu, T., Zhao, X., Wu, M., Li, Z., Luo, L., Yang, C., & Yang, F. (2022). Prevalence of depression in older adults: A systematic review and meta-analysis. Psychiatry Research, 311, 114511. https://doi.org/10.1016/j.psychres.2022.114511
Irandoust, K., & Taheri, M. (2017). The effect of vitamin D supplement and indoor vs outdoor physical activity on depression of obese depressed women. Asian Journal of Sports Medicine, 8(3). https://doi.org/10.5812/asjsm.13311
Jorde, R., & Kubiak, J. (2018). No improvement in depressive symptoms by vitamin D supplementation: Results from a randomised controlled trial. Journal of Nutritional Science, 7, 1–7. https://doi.org/10.1017/jns.2018.19
Kaviani, M., Nikooyeh, B., Zand, H., Yaghmaei, P., & Neyestani, T. R. (2020). Effects of vitamin D supplementation on depression and some involved neurotransmitters. Journal of Affective Disorders, 269(March), 28–35. https://doi.org/10.1016/j.jad.2020.03.029
Khan, B., Shafiq, H., Abbas, S., Jabeen, S., Khan, S. A., Afsar, T., Almajwal, A., Alruwaili, N. W., Al-Disi, D., Alenezi, S., Parveen, Z., & Razak, S. (2022). Vitamin D status and its correlation to depression. Annals of General Psychiatry, 21(1), 1–9. https://doi.org/10.1186/s12991-022-00406-1
Lerner, P. P., Sharony, L., & Miodownik, C. (2018). Association between mental disorders, cognitive disturbances and vitamin D serum level: Current state. Clinical Nutrition ESPEN, 23, 89–102. https://doi.org/10.1016/j.clnesp.2017.11.011
Libuda, L., Laabs, B. H., Ludwig, C., Bühlmeier, J., Antel, J., Hinney, A., Naaresh, R., Föcker, M., Hebebrand, J., König, I. R., & Peters, T. (2019). Vitamin D and the risk of depression: A causal relationship? Findings from a Mendelian randomization study. Nutrients, 11(5). https://doi.org/10.3390/nu11051085
Menon, V., Kar, S. K., Suthar, N., & Nebhinani, N. (2020). Vitamin D and depression: A critical appraisal of the evidence and future directions. Indian Journal of Psychological Medicine, 42(1), 11–21. https://doi.org/10.4103/IJPSYM.IJPSYM_160_19
Meshkin, A., Badiee, F., Salari, N., Hassanabadi, M., Khaleghi, A. A., & Mohammadi, M. (2024). The global prevalence of vitamin D deficiency in the elderly: A meta-analysis. Indian Journal of Orthopaedics, 58(3), 223–230. https://doi.org/10.1007/s43465-023-01089-w
Mikola, T., Marx, W., Lane, M. M., Hockey, M., Loughman, A., Rajapolvi, S., Rocks, T., O’Neil, A., Mischoulon, D., Valkonen-Korhonen, M., Lehto, S. M., & Ruusunen, A. (2023). The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta‐analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition, 63(33), 11784–11801. https://doi.org/10.1080/10408398.2022.2096560
Okereke, O. I., Reynolds, C. F., Mischoulon, D., Chang, G., Vyas, C. M., Cook, N. R., Weinberg, A., Bubes, V., Copeland, T., Friedenberg, G., Lee, I. M., Buring, J. E., & Manson, J. E. (2020). Effect of long-term vitamin D3 supplementation vs placebo on risk of depression or clinically relevant depressive symptoms and on change in mood scores: A randomized clinical trial. JAMA, 324(5), 471–480. https://doi.org/10.1001/jama.2020.10224
Pludowski, P., Grant, W. B., Karras, S. N., Zittermann, A., & Pilz, S. (2024). Vitamin D supplementation: A review of the evidence arguing for a daily dose of 2000 international units (50 µg) of vitamin D for adults in the general population. Nutrients, 16(3), 391. https://doi.org/10.3390/nu16030391
Pu, D., Luo, J., Wang, Y., Ju, B., Lv, X., Fan, P., & He, L. (2018). Prevalence of depression and anxiety in rheumatoid arthritis patients and their associations with serum vitamin D level. Clinical Rheumatology, 37(1), 179–184. https://doi.org/10.1007/s10067-017-3874-4
Putranto, R., Adhiatma, K., Tarigan, T. J. E., Rumende, C. M., Shatri, H., Rengganis, I., Nugroho, P., & Rinaldi, I. (2023). Vitamin D levels and depression in type 2 diabetes mellitus patients: A cross-sectional study. Medical Journal of Indonesia, 32(3), 177–182. https://doi.org/10.13181/mji.oa.237005
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Jurnal Kesehatan Amanah

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.