Korelasi Profil Darah dan Komposisi Tubuh terhadap Kelembapan Kulit: Tinjauan Empiris Kelompok Dewasa di Tiga Institusi Pendidikan
DOI:
https://doi.org/10.57214/jka.v9i1.926Keywords:
body composition, hemoglobin, skin hydration, triglyceride, uric acidAbstract
Background: Skin hydration is influenced by both intrinsic and systemic factors, including blood biomarkers and body composition. Physiological conditions such as anemia, dyslipidemia, and hyperuricemia are known to affect skin barrier function; however, their relationship with skin hydration has not been comprehensively studied in healthy adult populations. Objective: To analyze the association between blood parameters (hemoglobin, fasting blood glucose, uric acid, total cholesterol, HDL, LDL, and triglycerides) and body composition (visceral fat, subcutaneous fat, skeletal muscle mass) with skin hydration status (water, oil, and moisture levels) in adults. Methods: A cross-sectional study was conducted on 210 adult participants from three educational institutions in Jakarta. Data were collected through fasting venous blood analysis, bioelectrical impedance measurements, and skin analysis. Statistical analysis used Spearman correlation with a significance level of p<0.05. Results: Hemoglobin, triglycerides, and uric acid showed a significant positive correlation with skin hydration (p<0.01), while total cholesterol, LDL, HDL, and body composition parameters did not show significant associations. Fasting blood glucose was also not significantly correlated with skin moisture. Conclusion: Certain blood parameters, particularly hemoglobin, triglycerides, and uric acid, play an important role in maintaining skin hydration. These findings highlight the importance of evaluating systemic biomarkers as part of a comprehensive approach in skin care and in preventing dry skin in adult populations.
References
Arnaboldi, F., Busnelli, M., Cornaghi, L., Manzini, S., Parolini, C., Dellera, F., Ganzetti, G. S., Sirtori, C. R., Donetti, E., & Chiesa, G. (2015). High-density lipoprotein deficiency in genetically modified mice deeply affects skin morphology: A structural and ultrastructural study. Experimental Cell Research, 338(1), 105-112. https://doi.org/10.1016/j.yexcr.2015.07.032
https://doi.org/10.1016/j.yexcr.2015.07.032
Berdyshev, E. (2024). Skin Lipid Barrier: Structure, Function and Metabolism. Allergy, Asthma & Immunology Research, 16(5), 445-461. https://doi.org/10.4168/aair.2024.16.5.445
https://doi.org/10.4168/aair.2024.16.5.445
Brinkman, J. E., Dorius, B., & Sharma, S. (2024). Physiology, Body Fluids. In StatPearls.
Camilion, J. V, Khanna, S., Anasseri, S., Laney, C., & Mayrovitz, H. N. (2022). Physiological, Pathological, and Circadian Factors Impacting Skin Hydration. Cureus. https://doi.org/10.7759/cureus.27666
https://doi.org/10.7759/cureus.27666
de Macedo, G. M. C., Nunes, S., & Barreto, T. (2016). Skin disorders in diabetes mellitus: an epidemiology and physiopathology review. Diabetology & Metabolic Syndrome, 8(1), 63. https://doi.org/10.1186/s13098-016-0176-y
https://doi.org/10.1186/s13098-016-0176-y
Destra, E., Anggraeni, N., Firmansyah, Y., & Santoso, A. H. (2023). Waist to hip ratio in Cardiovascular Disease Risk: A Review of the Literature. MAHESA: Malahayati Health Student Journal, 3(6), 1770-1781. https://doi.org/10.33024/mahesa.v3i6.10595
https://doi.org/10.33024/mahesa.v3i6.10595
Drakou, K., Tsianni, A., Vrani, F., Kefala, V., & Rallis, E. (2021). Revealing the Correlation between Altered Skin Lipids Composition and Skin Disorders. Cosmetics, 8(3), 88. https://doi.org/10.3390/cosmetics8030088
https://doi.org/10.3390/cosmetics8030088
Fahad, D., & Mohammed, M. T. (2020). Oxidative Stress: Implications on Skin Diseases. Plant Archives, 20(2), 4150-4157.
Fluhr, J. W., Moore, D. J., Lane, M. E., Lachmann, N., & Rawlings, A. V. (2024). Epidermal barrier function in dry, flaky and sensitive skin: A narrative review. Journal of the European Academy of Dermatology and Venereology, 38(5), 812-820. https://doi.org/10.1111/jdv.19745
https://doi.org/10.1111/jdv.19745
Gade, A., Matin, T., & Rubenstein, R. (2024). Xeroderma. In StatPearls.
Gidado, I. M., Qassem, M., Triantis, I. F., & Kyriacou, P. A. (2022). Review of Advances in the Measurement of Skin Hydration Based on Sensing of Optical and Electrical Tissue Properties. Sensors (Basel, Switzerland), 22(19). https://doi.org/10.3390/s22197151
https://doi.org/10.3390/s22197151
Hutagalung, P. S. U. B., Jusuf, N. K., & Paramita, D. A. (2024). Correlation between Hypoxia Inducible Factor-1 Alpha (HIF-1α) levels with hydration of skin aging. Bali Medical Journal, 14(1), 390-393. https://doi.org/10.15562/bmj.v14i1.5559
https://doi.org/10.15562/bmj.v14i1.5559
Kawai, T., Autieri, M. V, & Scalia, R. (2021). Adipose tissue inflammation and metabolic dysfunction in obesity. American Journal of Physiology. Cell Physiology, 320(3), C375-C391. https://doi.org/10.1152/ajpcell.00379.2020
https://doi.org/10.1152/ajpcell.00379.2020
Kim, J. H., Kwack, M. H., & Lee, W. J. (2024). Effects of antioxidants on skin hydration, inflammatory cytokines, and keratinocyte differentiation markers in a PM 10-exposed skin barrier-disrupted mouse model. International Journal of Immunopathology and Pharmacology, 38. https://doi.org/10.1177/03946320241303860
https://doi.org/10.1177/03946320241303860
Lai, C. C. K., Md Nor, N., Kamaruddin, N. A., Jamil, A., & Safian, N. (2021). Comparison of transepidermal water loss and skin hydration in diabetics and nondiabetics. Clinical and Experimental Dermatology, 46(1), 58-64. https://doi.org/10.1111/ced.14363
https://doi.org/10.1111/ced.14363
Lee, N. H. (2020). Iron Deficiency Anemia. Clinical Pediatric Hematology-Oncology, 27(2), 101-112. https://doi.org/10.15264/cpho.2020.27.2.101
https://doi.org/10.15264/cpho.2020.27.2.101
Martins Cardoso, R., Creemers, E., Absalah, S., Gooris, G. S., Hoekstra, M., Van Eck, M., & Bouwstra, J. A. (2019). Hypercholesterolemia in young adult APOE −/− mice alters epidermal lipid composition and impairs barrier function. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864(7), 976-984. https://doi.org/10.1016/j.bbalip.2019.03.008
https://doi.org/10.1016/j.bbalip.2019.03.008
Mori, S., Shiraishi, A., Epplen, K., Butcher, D., Murase, D., Yasuda, Y., & Murase, T. (2017). Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women. Lipids in Health and Disease, 16(1), 214. https://doi.org/10.1186/s12944-017-0608-1
https://doi.org/10.1186/s12944-017-0608-1
Nguyen, C., & Li, M. (2024). Iron Deficiency Anemia Pruritus: A Review with Proposed Mechanisms of Action. SKIN The Journal of Cutaneous Medicine, 8(2), 1365-1373. https://doi.org/10.25251/skin.8.2.2
https://doi.org/10.25251/skin.8.2.2
Popkin, B. M., D'Anci, K. E., & Rosenberg, I. H. (2010). Water, hydration, and health. Nutrition Reviews, 68(8), 439-458. https://doi.org/10.1111/j.1753-4887.2010.00304.x
https://doi.org/10.1111/j.1753-4887.2010.00304.x
Proksch, E., Berardesca, E., Misery, L., Engblom, J., & Bouwstra, J. (2020). Dry skin management: practical approach in light of latest research on skin structure and function. Journal of Dermatological Treatment, 31(7), 716-722. https://doi.org/10.1080/09546634.2019.1607024
https://doi.org/10.1080/09546634.2019.1607024
Susanto, C., Yosi, A., & Roesyanto-Mahadi, I. D. (2025). The Correlation of Body Mass Index and Skin Hydration in Diabetic Patients. Romanian Journal of Diabetes, Nutrition and Metabolic Diseases, 32(1), 15-19. https://doi.org/10.46389/rjd-2025-1813
Weber, S. U., Thiele, J. J., Packer, L., & Cross, C. E. (1999). Vitamin C, Uric Acid, and Glutathione Gradients in Murine Stratum Corneum and their Susceptibility to Ozone Exposure. Journal of Investigative Dermatology, 113(6), 1128-1132. https://doi.org/10.1046/j.1523-1747.1999.00789.x
https://doi.org/10.1046/j.1523-1747.1999.00789.x
Wong, W. J., Richardson, T., Seykora, J. T., Cotsarelis, G., & Simon, M. C. (2015). Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. The Journal of Investigative Dermatology, 135(2), 454-461. https://doi.org/10.1038/jid.2014.283
https://doi.org/10.1038/jid.2014.283
Ye, X., Tong, Z., Dang, Y., Tu, Q., Weng, Y., Liu, J., & Zhang, Z. (2010). Effects of Blood Glucose Fluctuation on Skin Biophysical Properties, Structure and Antioxidant Status in An Animal Model. Clinical and Experimental Dermatology, 35(1), 78-82. https://doi.org/10.1111/j.1365-2230.2009.03361.x
https://doi.org/10.1111/j.1365-2230.2009.03361.x
Yew, Y. W., Mina, T., Ng, H. K., Lam, B. C. C., Riboli, E., Lee, E. S., Lee, J., Ngeow, J., Elliott, P., Thng, S. T. G., Chambers, J. C., & Loh, M. (2023). Investigating causal relationships between obesity and skin barrier function in a multi-ethnic Asian general population cohort. International Journal of Obesity (2005), 47(10), 963-969. https://doi.org/10.1038/s41366-023-01343-z
https://doi.org/10.1038/s41366-023-01343-z
Yousef, H., Alhajj, M., & Sharma, S. (2024). Anatomy, Skin (Integument), Epidermis. In StatPearls.
Yulianti, L., Destra, E., Gunaidi, F. C., Gracienne, G., & Kusuma, K. F. (2024). Kegiatan Skrining Kadar Air Dan Minyak Kulit Pada Populasi Lanjut Usia. NUSANTARA Jurnal Pengabdian Kepada Masyarakat, 4(2), 57-64. https://doi.org/10.55606/nusantara.v4i2.2835
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