Uji Efektivitas Ekstrak Etanol Daun Lire (Hemigraphis repanda (L) Hall F) Sebagai Antipiretik Pada Tikus Putih (Rattus norvegicus)
DOI:
https://doi.org/10.57214/jusika.v5i1.181Keywords:
Antipyretic Effect, White Rats, Lire Leaf Extract, Peptone 5%.Abstract
Fever can be interpreted as a body temperature that is higher (>37°C) than normal temperature because of the temperature control center in the hypothalamus, the temperature control center balances temperature during health or fever by regulating the formation and release of heat. For this reason, the purpose of this study was to determine the antipyretic effectiveness of various concentrations of extracts. In this study, 5% peptone was used to induce fever in 15 white rats which were divided into 5 treatment groups. Groups 1 was given 1% NaCMC as a negative control, groups 2 was given paracetamol 9 mg/200gBB) as a positive control, groups 3 was given 10% lire leaf extract (2 mg/200gBB), groups 4 was given 20% lire leaf extract (4 mg/200gBB), and groups 5 was given 40% lire leaf extract (8 mg/200gBB). This results of this study obtained extract levels of 7,44% and there was a weak antipyretic effect at concentrations of 10% and 20% lire leaf extract, while the greatest antipyretic effect was found in 40% lire leaf extract, almost comparable to 9 mg paracetamol.
References
Ermawati, E. F. (2010). Efek Antipiretik Ekstrak Daun Pare (Momordica Charatina L.) Pada Tikus Putih Jantan. Skripsi.
Odding, H. A. (2016). Uji Aktivitas Antipiretik Ekstrak Etanol Daun Srikaya (Annona squamosa Linn.) Terhadap Mencit (Mus Musculus) Jantan. Skripsi. Fakultas Kedokteran dan Ilmu Kesehatan. Universitas Islam Negeri Alauddin. Makassar.
Parwata, I. M. (2016). Obat Tradisional. Bukit jimbaran.
Pelokang, C. Y., Koneri, R., & Katili, D. (2018). Pemanfaatan Tumbuhan Obat Tradisional oleh Etnis Sangihe di Kepulauan. Biologis FMIPA.
Rompas, D. E., Runtuwene, M. R., & Koleangan, H. S. (2016). Analisis Kandungan Fitokimia dan Uji Aktivitas Antioksidan dari Tanaman Lire (Hemigraphis repanada (L) Hall F.). Jurnal MIPA, 36-39. Jurusan kimia, FMIPA. Universitas Sam Ratulangi. Manado.
Widyasari, R., Yuspitasari, D., Fadli, Masykuroh, A., & Tahuhiddah, W. (2018, Juni). Uji Aktivitas Antipiretik Ekstrak Daun Sisik Naga (Pyrrosia piloselloides (L.) M.G. Price) Terhadap Tikus Putih (Rattus norvegicus) Jantan Galur Wistar Yang Diinduksi Pepton 5%. Jurnal Ilmu Farmasi dan Farmasi Klinik (JIFFK), Vol. 15, No.1(ISSN : 1693-7899), 22-28. Akademi Farmasi Yarsi Pontianak.
